Dr. Phillip A. Sharp, Ph.D.

Institute Professor, Massachusetts Institute of Technology
Department of Biology, and Koch Institute for Integrative Cancer Research


1993 Nobel Prize in Physiology or Medicine
2004 National Medal of Science

A native of Kentucky, Dr. Sharp earned a B.A. degree from Union College, KY and a PhD in chemistry from the University of Illinois, Champaign-Urbana. Prior to joining MIT, he was Senior Scientist at Cold Spring Harbor Laboratory. He is co-founder of Biogen Idec and Alnylam Pharmaceuticals.

In February 2013 at the AAAS/AJAS annual meeting in Boston, Dr. Sharp praised the AJAS delegates during their visit to MIT "The American Junior Academy of Science recognizes the remarkable achievements of young scientists in independent research," he said. “Their projects have been selected from across the nation as the most outstanding and we congratulate them.”

Phillip Sharp has made fundamental contributions to cancer biology and to understanding gene structure and regulation. Sharp’s seminal discovery of ‘split genes’ in eukaryotic cells and the associated mechanism of pre-mRNA splicing resulted in numerous awards and honors, including the Nobel Prize in Physiology or Medicine (1993), the Lasker Prize (1988), the Gairdner Foundation International Award (1986) and the 2004 National Medal of Science. Over the years, his laboratory has developed technology for the biochemical characterization of protein complexes and interactions of factors with DNA and RNA. More recently, his laboratory contributed to the recognition of the fascinating roles of noncoding RNAs in processes related to RNAi and gene regulation. Dr. Sharp has authored over 400 papers. He serves on many advisory boards for the government, academic institutions, scientific societies, and companies.

His long list of service includes the presidency of the AAAS (2013) and Chair of the Scientific Advisory Committee, SU2C Project, AACR.

Dr. Phil Sharp is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, the American Philosophical Society, and the Royal Society of the UK.




A link to a videotaped conversation https://biology.mit.edu/about/conversation_scientists_phillip_sharp

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